2025 Week 8 College Football Best Bets
2025 Week 8 College Football Best Bets
The college football season continues to roll along, and each week, we are delivered great games after great games on a weekly basis. Indiana went into Eugene to knock off Oregon. Texas won the Red River Showdown. South Florida, Ohio State, Alabama, Georgia, and BYU all went into enemy territory and won on the road. Others, like Michigan, Arizona State, Iowa State, and Florida State, found themselves among ranked teams to lose to unranked foes.
Week 8 offers another incredible Saturday full of football. Five ranked matchups, including three in the SEC. Not to mention plenty of teams fighting for their bowl lives, or even college football playoff lives. Here are my favorite Week 8 college football plays.
Odds courtesy of DraftKings Sportsbook. Lines are subject to change. Please gamble responsibly and within your means. Gambling problem? Call 1-800-GAMBLER.
More: Week 7 Fantasy Football Rankings (2025)
Week 7: 3-2 (+0.75 units)
Year to Date: 15-20 (-7.35 units)
Washington (5-1) vs. Michigan (4-2)
Michigan -6; O/U 50.5
Michigan -6 (-112)
Washington is 0-5 ATS in road Big Ten teams when they travel east since conference realignment last year. Factor in this is a 9 AM local kickoff for the Huskies. For Michigan, Bryce Underwood has been significantly better at home than on the road. In Ann Arbor, Underwood averages 9.0 YPA while completing 66.7% of his attempts; on the road, Underwood averages 6.5 YPA and completes just 51.4% of his passes. I think this sets up to be a good bounce back spot for Underwood and the Wolverines to keep their College Football Playoff hopes alive. I’m on the Wolverines to cover the number in this one.
More: 2025 College Football Playoff Landscape
Buffalo (3-3) vs. Massachusetts (0-6)
Massachusetts +16.5; O/U 45.5
Buffalo -16.5 (-112)
This is simply a fade of UMass, a team that just allowed 42 points to Kent State. A Kent State team that has not won a MAC conference game November 22nd, 2022. That was also their last win over a FBS opponent as well. Buffalo is coming off a bye after their overtime win over Eastern Michigan. In the first year with Pete Lambo as head coach, Buffalo won 30-15 as a 10.5-point underdog over Toledo. I like Buffalo to win this one big on the road.
Michigan State (3-3) vs. #3 Indiana (6-0)
Indiana -27.5; O/U 52.5
Over 52.5 (-108)
Curt Cignetti and the Hoosiers shocked the college football world last week, going into Autzen and defeating the then-ranked #3 Oregon Ducks. While a letdown spot can happen, Cignetti has prefaced that their sites are onto this week.
Michigan State has allowed at least 38 points in each of their three Big Ten games. Even going back to last year when Jonathan Smith took over, the Spartans defense allows 33.4 PPG. Home games with Cignetti and offensive coordinator Mike Shanahan, Indiana has averaged 46.3 PPG. The over has cashed in four of those six games. I think this one clears the number.
More: 2025 College Football Futures
#5 Ole Miss (6-0) vs. #9 Georgia (5-1)
Georgia -7.5; O/U 54.5
3rd Quarter: Georgia -1.5 (-115)
This is a niche line, but there is logic behind this pick. In four SEC games this year, Georgia has been outscored 62-55 in the first half. In the 3rd quarter, Georgia has outscored opponents 41-7. The only time the Bulldogs allowed a point in the 3rd quarter came against Tennessee, when Chris Brazzell II moss’d a defender for a 56-yard touchdown with 7 seconds left in the quarter. I trust Kirby Smart to make the right second half adjustments to get Georgia in a position to win the game. Georgia covers this number coming out of the half.
#22 Memphis (6-0) vs. UAB (2-4)
UAB +21.5; O/U 63.5
Memphis -21.5 (-110)
Three teams are perfect against the spread this year: Ohio State, Texas Tech, and Memphis. The American is the best conference among Group of Six schools, with five teams currently in the race to represent in the college football playoff. Style points matter for the smaller schools; any signs of close games against inferior opponents could go against them. Trent Dilfer is out at UAB – this likely got swept under the rug after Penn State’s James Franklin firing. I believe Memphis clears this number in a dominating road win.
More: Fantasy Notebook: Target & Snap Share Data from Week 6 (2025)
Outright Underdogs (.5 units)
Week 7: 0-2 (-1.00 units)
Year to Date: 11-12 (+3.08 units)
(Friday) Minnesota vs. #25 Nebraska +240
Are there distractions in Lincoln with Matt Rhule’s name floating around the Penn State opening? Even so, the Cornhuskers tend to play in close games. I like Minnesota to keep to win this one as a home dog.
#12 Georgia Tech @ Duke +100
In the three full seasons that Brent Keys has been the Georgia Tech head coach, the Yellow Jackets are 11-5 ATS. Both teams have a lot to play for, but Tech has little room for wiggle room if they want in without winning the ACC Championship. I’m on the Yellow Jackets to win this one.
South Carolina vs. #14 Oklahoma +180
The Gamecocks are 3-4 against Power Four ranked opponents since Shane Beamer took over. Oklahoma just lost to their biggest rival and has Ole Miss on deck. Perfect trap spot for the Sooners. I’m on South Carolina for the upset.
SMU @ Clemson +185
Sounds like Cade Klubnik will not go for Clemson this week. SMU still has sights on the College Football Playoff if they can make it to Charlotte for the ACC Championship. This is a must have for SMU. I’m on the Mustangs to win in Death Valley.
Auburn vs. #16 Missouri +105
Auburn has played well against ranked opponents this year, keeping two of the three within one score and blowing a 10-point game last week to Georgia. They are due for one against one of these ranked SEC teams. On October 18th, Missouri has just their first road game of the year. The Tigers are 7-13 in true road games in conference play with Eli Drinkwitz. I’m on the (Auburn) Tigers in this one.
What is your favorite 2025 week 8 college football best bets? Let me know on X!
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