2025 NFL Week 6 Best Bets
2025 NFL Week 6 Best Bets
The first week of October signaled the end of the last unbeaten teams. And while the Jets search for their first win of the season, both conferences find teams jostling for position at the top. There is still plenty of time for all teams to bounce back as we head towards the halfway point of the season. Here are my week 6 best bets in the NFL.
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Week 5: 2-1 (+.92 units)
Year to Date: 10-9 (-0.08 units)
Cleveland Browns (1-4) vs. Pittsburgh Steelers (3-1)
Pittsburgh -5.5; O/U 37.5
Pittsburgh -5.5 (-105)
Cleveland: Team Total Under 16.5 (-118)
Both the Browns and Steelers traveled abroad for their last game, with the Browns playing in London and Pittsburgh playing in Dublin. However, the Steelers have a big advantage in this one as they come off their bye, while Cleveland just played on Sunday. Dillon Gabriel will get his second start but first in a true road environment. Against the Vikings, the 3rd round rookie averaged 5.76 YPA while the team averaged 4.81 YPP. Pittsburgh is 5-0 ATS coming off their bye week since the Covid-19 season. I’m on the Steelers to win and cover in this low scoring AFC North showdown.
San Francisco 49ers (4-1) vs. Tampa Bay Buccaneers (4-1)
Tampa Bay -3; O/U 47.5
Tampa Bay -3 (-120)
The 49ers have a laundry list of players expected to miss. Brandon Aiyuk and George Kittle are already out, while Brock Purdy and Ricky Pearsall are also expected to miss. Purdy’s replacement, Mac Jones, popped up on the injury report with a knee injury but is expected to play. Tampa Bay has played in exciting games this year, with each game being close in the 4th quarter and being one possession. While they are without Mike Evans and likely Bucky Irving on offense, they have proven replacements in rookie Emeka Egbuka and Rachaad White. I think this will be another fun game with the Buccaneers covering the number.
Los Angeles Rams (3-2) vs. Baltimore Ravens (1-4)
Baltimore +7.5; O/U 44.5
Over 44.5 (-115)
Only four teams in the NFL have allowed over 30 points per game on average this year. Only one allows over 32, with that team being the Ravens; they allow 35.4 PPG. The Ravens have played four playoff teams from the 2024 season, with each team scoring 37 or more points. Now the Rams come to town, where they have scored 59 points total in their two games traveling east this year. Cooper Rush gets his second start for the Ravens, and I believe their offense will contribute to the point total more than last week. I’m on the over in this one.
Outright Underdogs (.5 Units):
Week 5: 1-1 (+0.15 units)
Year to Date: 2-7 (-2.28 units)
Miami vs. Los Angeles (A) +180
The Chargers head east and have been hit hard with injuries to start the season. They are without their top two tackles and top two running backs. While Justin Herbert is perfectly capable to lead this team to victory, he has been sacked seven times in the last two games. I think Miami pulls the upset against the Chargers.
What are some of your favorite Week 6 NFL best bets? Let me know on X! Follow me @DrewRoberts_ on X for more football content!


