2025 Week 7 College Football Best Bets
2025 Week 7 College Football Best Bets
The last two weeks have kept college football fans on the edge of their seats. Between top ranked matchups, to upsets, to the upsets no one saw coming. The last few weeks have been absolute cinema as we get one week closer to determining who makes the 12-team College Football Playoff. Week 7 is no different, as we have another top-10 matchup in the Big Ten, two additional ranked matchups in Ohio State and Illinois, and Alabama and Missouri. Not to mention some big rivalry games and Group of Six matchups that could determine who makes the playoff. Here are my favorite Week 7 college football plays.
Odds courtesy of DraftKings Sportsbook. Lines are subject to change. Please gamble responsibly and within your means. Gambling problem? Call 1-800-GAMBLER.
More: Week 6 Fantasy Football Rankings (2025)
Week 6: 1-4 (-3.38 units)
Year to Date: 12-18 (-8.10 units)
#1 Ohio State (5-0) vs. #17 Illinois (5-1)
Illinois +14; O/U 49.5
Ohio State -14 (-115)
Illinois: Team Total Under 16.5 (+100)
This Ohio State team has handled business this year, going 4-0-1 ATS on the season. And while road contests are tricky spots for top ranked opponents, Ryan Day and the Buckeyes have been solid early in the Big Ten season. Ohio State is 40-1 in their first three Big Ten games of the season going back to 2011.
Ohio State has not allowed an opponent to hit double digits this year. Matt Patricia has done a phenomenal job of getting this Buckeyes defense ready after losing multiple key four-year starters in April’s NFL Draft. Since Brent Bielema took over as Illini head coach in 2021, there are four instances of playing a top-10 team. Illinois has 46 total points in those games (11.5 PPG), only hitting 17 points in one contest. Indiana displayed the gameplan to beat up on Illinois’s offensive line to slow down their offense. Ohio State has more guys than Indiana, and I think they take care of this one. Buckeyes, big.
More: 2025 College Football Futures
#8 Alabama (4-1) vs. #14 Missouri (5-0)
Missouri +3; O/U 51.5
Over 51.5 (-110)
Alabama has been humming since being embarrassed in week one against Florida State. Since then, Alabama has scored 30.7 PPG against three Power Four programs, including a road contest at Georgia. Ty Simpson has been near perfect since the loss; in those three Power Four wins, Simpson is completing 72.4% of his attempts for 10.2 YPA, throwing eight touchdowns to one interception. Crimson Tide running back Jam Miller missed the first three games, but returned at Georgia on September 27th. He’s coming off a game against Vanderbilt where he rushed 22 times for 136 yards (6.2 YPC) and one score.
Missouri has been a strong team at home, especially offensively. In their last 12 home games against Power Four opponents, the Tigers are averaging 31.6 PPG, scoring at least 30 in eight of those games. Beau Pribula is a mobile quarterback, and that type of quarterback has tended to give Kane Wommack and the Alabama defense fits, especially on the road. I like this SEC matchup to clear the 51.5-point total.
#7 Indiana (5-0) vs. #3 Oregon (5-0)
Oregon -7; O/U 55.5
Oregon -7 (-115)
I love my Hoosiers. These last two years with Curt Cignetti and company has been the best two year stretch in program history. But the one concern with this team since the start of 2024 is how they play when taking a step up in competition. Specifically, on the road.
In a small sample size, we saw the Hoosiers trail Ohio State in Columbus 28-7 entering the 4th quarter. Against Notre Dame in the College Football Playoff, they trailed 20-3 entering the 4th. In both games, they managed to close the gap to make the final score closer. Now they travel across the country to Eugene to play another team with top tier talent and a national title contender. I hope I’m wrong, but until I see Indiana go toe-to-toe with that type of talent, I’ll fade the Hoosiers. I’m on Oregon to clear this number.
#15 Michigan (4-1) vs. USC (4-1)
USC -2.5; O/U 57.5
USC -2.5 (-112)
When USC plays at home in conference play, the Trojans are 4-1 SU and ATS. On the road, they are 1-4 head to head and 0-5 ATS. Michigan heads west for their second away game this year; the first ended up being a 24-13 loss to Oklahoma in Norman. Bryce Underwood did not play great, completing just 37.5% of his attempts for 5.92 YPA. While Oklahoma’s defense is significantly better than USC’s, I think USC’s offense is head and shoulders above Oklahoma’s. Can Michigan hang with Jayden Maiava and the pair of Ja’Kobi Lane and Makai Lemon? I’m not so sure. Give me the Trojans to win and cover at the Rose Bowl.
More: Fantasy Notebook: Target & Snap Share Data from Week 5 (2025)
Outright Underdogs (.5 units)
Week 6: 2-2 (+.63 units)
Year to Date: 11-10 (+4.08 units)
#14 Missouri vs. #8 Alabama +136
Alabama has struggled in two areas – on the road (2-3 in SEC play under DeBoer) and against mobile quarterbacks. Welcome to Columbia, Missouri, where they face a mobile Beau Pribula and an Eli Drinkwitz team that is 8-1 in home SEC games since 2023. I’m on the Tigers to remain undefeated.
Maryland vs. Nebraska +205
Maryland blew a 20-point lead to Washington last week, and now welcome 4-1 Nebraska to College Park. This is Nebraska’s first true road contest of the year. Dylan Raiola as a freshman was just 1-5 on the road with the lone win coming at Purdue, who was winless against FBS teams last year. Nebraska scored 16.8 PPG in those contests. I’m on Maryland to pull the home upset.
What is your favorite 2025 week 7 college football best bets? Let me know on X!
Follow @drewroberts_ and let’s discuss any football topic you’d like
