2025 Week 10 College Football Best Bets
2025 Week 10 College Football Best Bets
Week 9 in the college football universe was mild compared to previous weeks. No results were shocking – South Florida and Illinois lost to unranked teams, but did so on the road. Arizona State lost at home to Houston, but lost Sam Leavitt during the game. Alabama, Virginia, and Texas all had scares, with Virginia and Texas surviving in overtime. Similar to week 9, we have three ranked matchups. Two come in the SEC, while Cincinnati travels to Utah for the lone such matchup in the Big 12. Nonetheless, there are still plenty of matchups with College Football Playoff and bowl eligibility ramifications on the line. Here are my Week 10 college football best bets.
Odds courtesy of DraftKings Sportsbook. Lines are subject to change. Please gamble responsibly and within your means. Gambling problem? Call 1-800-GAMBLER.
More: Week 9 Fantasy Football Rankings (2025)
Week 9: 2-1 (+0.81 units)
Year to Date: 18-25 (-9.88 units)
#10 Miami (FL) (6-1) vs. SMU (5-3)
SMU +12.5; O/U 50.5
SMU +12.5 (-112)
On November 1st, Miami will leave the state of Florida for the first time this year. Mario Cristobal is just 4-8 SU in the month of November since he took the Miami head coaching position. In five true road games going back to 2024, Carson Beck is just 3-2 (2-3 ATS). Beck has thrown seven touchdowns to seven interceptions in road games against Power Four programs; this improves to 15 touchdowns to seven interceptions across eight home contests. SMU suffered a look ahead spot loss last week to Wake Forest. Now they can play spoiler and drop Miami from the playoff ranks. I’m on the Mustangs as home dogs.
More: 2025 College Football Futures
Navy (7-0) vs. North Texas (7-1)
North Texas -6.5; O/U 65.5
Over 65.5 (-110)
This is the highest game total of the week. And while I tend to avoid those totals, all I see are points being scored in this one.
Blake Horvath is a great fit for Navy’s offense. Going back to 2023, in American games -excluding Army’s triple option – with Horvath under center, Navy averages 35.8 PPG. The average game total in those games is 56.8 PPG. The over cleared in eight of those games, with two of the unders coming to Rice, a slower tempo team. For North Texas, in four American games this year, the average game total is 82 PPG; every game has cleared 72 points. Drew Mestemaker just threw for over 600 yards last week. I think this one can get north of 80 if both offenses continue to roll. I’m on the over in this one.
#13 Texas Tech (7-1) vs. Kansas State (4-4)
Kansas State +7; O/U 51.5
Over 51.5 (-115)
Texas Tech was hot offensively to start the season, and that has continued in Big 12 play. The Red Raiders have scored at least 34 in four of five in Big 12 play, and seven of eight this year. Kansas State started the year slow, starting 1-3. Since then, the Wildcats have averaged 37.8 PPG and find themselves fighting for bowl eligibility. I think this one can be high scoring and am on the over for one of my week 10 college football best bets.
More: 2025 College Football Playoff Landscape
Oklahoma State (1-7) vs. Kansas (4-4)
Kansas -24.5; O/U 56.5
Kansas -24.5 (-112)
Oklahoma State is not only the worst Power Four program, it has also been profitable to fade the Cowboys against the spread. The Cowboys’ lone win this year came against FCS Tennessee Martin, and they are just 1-7 ATS with the lone cover coming to Baylor – by three points. They have failed to cover the last three since making the quarterback change to Sam Jackson V, being outscored 34-130.
Kansas is coming off of back to back losses and will be looking to take out some frustration on Oklahoma State. I’m locking the Jayhawks as one of my week 10 college football best bets.
Wake Forest (5-2) vs. Florida State (3-4)
Florida State -10; O/U 50.5
Wake Forest +10 (-112)
Florida State had a great run in 2023 and was robbed of a playoff berth. But since then, the Seminoles have been a trainwreck in ACC play. They are 1-11 in conference games since the start of 2024, going 2-9-1 ATS. Wake Forest has played well the last month, going 3-1 with the lone loss coming to Georgia Tech in overtime. The Demon Deacons covered each of those four games. I’m on Wake Forest to keep this one in single digits – or even win it outright.
More: Fantasy Notebook: Target & Snap Share Data from Week 8 (2025)
Outright Underdogs (.5 units)
Week 9: 0-5 (-2.50 units)
Year to Date: 14-19 (+2.21 units)
(Friday) North Carolina @ Syracuse +100
Since Syracuse quarterback Steve Angeli went down with an injury, the Orange have lost four straight by an average of 22.5 PPG. UNC seems to have turned a corner since the bye, losing by three at Cal and in overtime to Virginia. I think they finally get that ACC win and knock off Syracuse.
SMU vs. #10 Miami (FL) +360
I touched on this above, but I’m on SMU to win this one outright.
Wake Forest @ Florida State +270
Florida State comes off the bye, but are they looking ahead to Clemson next week? The Seminoles are just 1-11 in ACC play since the start of 2024. I’m on Wake Forest to pull the upset in Tallahassee this week.
What is your favorite 2025 week 10 college football best bets? Let me know on X!
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