2025 NFL Week 16 Best Bets
2025 NFL Week 16 Best Bets
Just three weeks remain in the regular season. Las week, we had just nine teams eliminated from postseason play. After week 15, that number is up to 13 with only the Rams and Broncos clinching a postseason berth. Plenty of spots are up for grabs, while others play for their postseason lives. Here are my week 16 best bets.
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Week 15: 1-4 (-3.40 units)
Year to Date: 35-25-1 (+7.53 units)
Las Vegas Raiders (2-12) vs. Houston Texans (9-5)
Houston -14.5; O/U 37.5
Houston -14.5 (-110)
Las Vegas has been a terrible watch this year, especially the last few weeks. All signs point to them as throwing in the towel. It doesn’t help they might be with backup Kenny Pickett, who led the Raiders offense to a whopping 75 total yards last week in Philadelphia. Now, they hit the road again to play a Texans’ team that is fighting to stay in the AFC playoffs. Houston’s offense got back on track since the return of CJ Stroud, as they are averaging 26.7 PPG while covering their last three games. I think this one could get ugly in Houston as the Texans roll.
Atlanta Falcons (5-9) vs. Arizona Cardinals (3-11)
Arizona +3; O/U 48.5
Over 48.5 (-105)
Jacoby Brissett has proved this year why he is a ten-year vet: he is a reliable backup option to turn to. Since he took the starting job in week 6, he has averaged over 300 passing yards per game while throwing 18 touchdowns to six interceptions. The Cardinals average 22.1 PPG in that nine-game span. No, it has not resulted in wins for the Cardinals due to a bottom tier defense that has allowed 32.4 PPG in the same span. The over is 7-2 in that span. Kirk Cousins has played well in two of the last three weeks and now gets extra rest after last Thursday’s win over the Bucs. That could help Atlanta’s top target, Drake London, return to the field. I’m on this one exceeding the point total.
New England Patriots (11-3) vs. Baltimore Ravens (7-7)
Baltimore -3; O/U 48.5
Baltimore -3 (-105)
Under 48.5 (-115)
The Ravens defense has picked it up since their bye week, allowing just 15.8 PPG. The under is 5-3 in that span with the average game total coming to 39.6 PPG, and only one game eclipsed this number. Prior to the bye, that number was inflated to 32.3 PPG. Now they welcome a New England team reeling after picking up their third loss of the year and first since September 21st. The 15th game on the Patriots’ schedule will be just the fifth of the year against a team at 500-or better. This is a desperate Baltimore team that cannot afford to lose any more ground to Pittsburgh in the AFC North race. I’m on the Ravens and the under for Sunday night football.
Outright Underdogs (.5 Units):
Week 15: 1-2 (+0.07 units)
Year to Date: 5-17 (-5.56 units)
Carolina vs. Tampa Bay +130
Carolina is now 0-12 in their last 12 games as a favorite. Now they find themselves in the underdog role again against a Tampa team that is healthy on offense, but a mess on defense. I’ll take Carolina to win this one outright to take control of the NFC South.
Los Angeles @ Dallas +110
Dallas is now mathematically eliminated from the postseason, unless the Eagles lose out and Dallas wins out. Los Angeles is now 4-4 SU as an underdog with Harbaugh and Herbert together. I think they go in and win in Jerry’s World.
What are some of your favorite week 16 best bets? Let me know on X! Follow me @DrewRoberts_ on X for more football content!


